Epigenetic Health Report (Muhdo)

Epigenetic analysis based on DNA methylation profiling, assessing biological age, organ function age, and inflammatory status.

Epigenetic Health Report (Muhdo)

Table of contents

Basic data

The Comprehensive Epigenetic Health Report (Muhdo) analyzes DNA methylation patterns to evaluate how lifestyle and environmental factors influence gene expression and biological aging. Unlike purely genetic tests, this report reflects how external factors — diet, sleep, exercise, and stress — have shaped the current functional state of your genome.

The test estimates overall biological age, the biological age of selected organ systems (vision, hearing, memory), and evaluates inflammatory and anti-inflammatory gene activity patterns. These metrics provide a snapshot of cellular health and recovery potential.

Although informative, epigenetic age tests should be interpreted cautiously. Results may vary due to sample quality and current physiological conditions (e.g., recent illness, stress, or inflammation), and they provide a momentary reflection rather than a long-term baseline.

Category: Epigenetics

Level: Advanced

Usefulness: Low

Level

Advanced

Advanced diagnostic designed for longevity and biohacking enthusiasts interested in tracking cellular aging and methylation dynamics. Requires proper context and repeat measurements to be meaningful.

Usefulness

Low

Epigenetic reports are intriguing for research and self-tracking purposes but currently offer limited practical usefulness for clinical or long-term decision-making.
Snapshot of current methylation status

Provides a one-time assessment of how lifestyle and environment have influenced your gene expression profile.

Useful for trend monitoring

When repeated over time, may show whether interventions (diet, exercise, stress management) slow or reverse biological aging patterns.

Limited actionability

Interpretation of methylation results is still evolving; most recommendations remain general rather than individualized.

How it works

The test measures methylation levels at specific CpG sites within your DNA — chemical markers that regulate gene activity without changing the DNA sequence itself.
Sample collection

A cheek swab or saliva sample is collected and sent to the Muhdo lab for epigenetic analysis.

Methylation profiling

DNA is processed using bisulfite sequencing technology to determine methylation intensity at loci associated with biological aging and inflammation.

Biological age modeling

The algorithm compares methylation data with reference datasets to estimate biological and organ-specific ages.

Measures

The report provides multiple indicators of cellular and functional aging, all derived from methylation analysis.
Biological age

Overall biological age compared with chronological age, reflecting cumulative lifestyle and environmental impact.

Organ-specific ages

Estimated biological age of sensory systems (vision, hearing) and cognitive function (memory), serving as proxies for system-level vitality.

Inflammatory balance

Assessment of pro-inflammatory vs. anti-inflammatory methylation patterns — indicating overall immune activation and tissue stress.

Anti-inflammatory gene activity

Evaluates methylation profiles of genes related to oxidative stress, inflammation, and immune regulation.

Reliability

Epigenetic methylation analysis is scientifically valid but sensitive to transient physiological factors.
Biological variability

Methylation states fluctuate with stress, sleep, diet, and acute inflammation, so a single result provides only a snapshot, not a stable baseline.

Technical precision

Laboratory reproducibility is generally high, but differences in preprocessing or normalization can influence results slightly.

Limitations

While insightful, the epigenetic health report has significant interpretive limitations and should not be treated as a diagnostic tool.
Not a medical diagnosis

The results describe gene regulation patterns, not diseases or clinical conditions.

Context-dependent interpretation

Methylation patterns can reflect recent stress, infections, or sleep deprivation rather than chronic biological aging.

No intervention specificity

The test cannot pinpoint which exact lifestyle factors caused the observed methylation profile.

Frequency

Suggested cadence

Every 6–12 months if used for monitoring the effect of lifestyle interventions on biological aging.

Cost

Typical costs

Approximately €200–400, depending on provider and whether multi-organ epigenetic analysis is included.

Availability

Where available

Offered by Muhdo and selected longevity clinics; usually requires direct-to-consumer DNA collection.

Preparation

How to prepare

Avoid eating, drinking, or brushing teeth for 30 minutes before sample collection; maintain stable sleep and stress conditions for several days prior to testing.

Interpretation

The results are color-coded and accompanied by practical recommendations; green indicates optimal methylation, yellow suggests mild deviation, and red signals accelerated aging or inflammation.
Green – optimal methylation

Indicates that biological and organ-specific ages are within the optimal range.

Yellow – moderate acceleration

Suggests mild deviation; possible effects of stress, poor sleep, or diet.

Red – accelerated aging or inflammation

Reflects increased pro-inflammatory gene activity or elevated biological age relative to chronological age.

Alternatives

TruDiagnostic TruAge

More comprehensive epigenetic analysis using advanced aging algorithms and DNA methylation clocks.

GlycanAge

Measures biological aging based on IgG glycan profiles, providing complementary insight into inflammation and immune system aging.

FAQ

Is the epigenetic test the same as a genetic test?

No. Genetic tests analyze fixed DNA sequences, while epigenetic tests evaluate how lifestyle and environment affect gene activity through methylation.

Can lifestyle changes alter methylation patterns?

Yes. Exercise, diet, stress management, and sleep quality can positively influence methylation and potentially slow biological aging.

How reliable is my biological age score?

Reliable within laboratory precision, but variable across time due to transient physiological and environmental factors.