OMICm Age (TruDiagnostic)

Epigenetic biological age estimation based on DNA methylation patterns across the genome.

OMICm Age (TruDiagnostic)

Table of contents

Basic data

The OMICm Age test by TruDiagnostic estimates an individual’s biological age using DNA methylation data derived from a blood sample. It compares the methylation status of specific CpG sites across the genome to large reference populations, generating an age prediction that reflects cumulative molecular and environmental influences on the body.

This test represents the primary epigenetic clock used in the TruAge platform and serves as a benchmark for assessing the overall biological aging rate. It integrates genomic, lifestyle, and environmental factors to determine whether one’s biological age is younger or older than their chronological age.

While it provides valuable insight into global aging processes, interpretation should be contextualized alongside other biomarkers such as DunedinPACE or physiological health metrics.

Category: Epigenetics

Level: Advanced

Usefulness: Low

Level

Advanced

This is an advanced-level diagnostic designed for users deeply interested in molecular longevity analytics. It requires laboratory DNA methylation sequencing and is primarily used in research or advanced personalized health programs. It offers perspective rather than clinical diagnosis.

Usefulness

Low

The OMICm Age clock provides an overview of biological aging derived from epigenetic data, but its individual diagnostic value remains limited without complementary context.
General aging benchmark

Offers a single biological age value reflecting cumulative exposure to aging processes, lifestyle, and environment.

Research and longevity tracking

Useful for longitudinal monitoring of biological age trends over time, particularly in intervention studies.

Limited actionable precision

While informative, results do not specify which physiological systems drive accelerated or decelerated aging.

How it works

The test analyzes DNA methylation levels at specific genomic sites using next-generation sequencing technology. These methylation markers correlate strongly with chronological age and biological function.
Sample collection

A small blood sample is collected and processed in a certified laboratory. DNA is extracted and prepared for analysis.

Methylation profiling

DNA methylation levels at thousands of CpG sites are quantified and compared with a reference dataset to calculate epigenetic age using the OMICm algorithm.

Measures

The report presents a primary biological age score and supporting data reflecting overall genomic methylation aging patterns.
OMICm Biological Age

The predicted biological age based on DNA methylation data.

Age Acceleration / Deceleration

The difference between biological and chronological age; a positive score indicates faster aging.

Reliability

TruDiagnostic’s OMICm Age clock is based on a large training dataset and validated across multiple cohorts. However, technical and biological variability should be considered.
Reproducibility

High reproducibility under standardized lab conditions using Illumina or next-generation methylation arrays.

Sources of variance

Methylation patterns may be influenced by temporary physiological states, inflammation, or sample handling.

Limitations

Although the test provides advanced molecular insights, it should not be interpreted as a direct measure of healthspan or disease risk.
Context dependence

Results must be interpreted alongside other biomarkers, such as inflammatory or metabolic markers.

Population-based reference

Predictions are derived from statistical averages and may not capture individual genetic or ethnic differences.

Frequency

Suggested cadence

Once per year or after major lifestyle interventions to assess long-term biological age trends.

Cost

Typical costs

Approximately €300–600 depending on the provider and inclusion in broader epigenetic testing panels.

Availability

Where available

Offered by TruDiagnostic and partner longevity clinics worldwide. Requires laboratory DNA methylation sequencing.

Preparation

How to prepare

No special preparation required. Avoid major infections or acute stress before blood draw for more stable results.

Interpretation

The report presents a calculated biological age and an “age acceleration” score indicating whether the user is aging faster or slower than expected.
Biological age younger than chronological age

Suggests slower molecular aging and positive lifestyle influence.

Biological age older than chronological age

Indicates accelerated molecular aging; further investigation of inflammation, metabolic health, or stress exposure may be warranted.

Alternatives

Horvath or Hannum Clocks

Earlier-generation DNA methylation clocks that estimate biological age but with lower predictive power for morbidity and mortality.

DunedinPACE (TruDiagnostic)

Measures the rate of aging rather than total biological age, providing complementary information.

FAQ

Is OMICm Age clinically validated?

It is scientifically validated across large datasets but not intended as a diagnostic or predictive medical test.

Can I reverse my biological age score?

Changes can be achieved through sustained lifestyle improvements, but due to biological noise, short-term fluctuations should not be overinterpreted.

Does a younger OMICm Age mean better health?

Generally yes, but it should be viewed as a global indicator rather than proof of superior health or reduced disease risk.