OMICm FitAge (TruDiagnostic)

Epigenetic biomarker estimating functional fitness age based on DNA methylation patterns linked to VO₂max and metabolic performance.

OMICm FitAge (TruDiagnostic)

Table of contents

Basic data

The OMICm FitAge test by TruDiagnostic provides an epigenetic estimate of functional fitness age, reflecting the body’s physiological capacity and cardiorespiratory health. It uses DNA methylation data to predict an equivalent “fitness age” that correlates with VO₂max, muscular efficiency, and overall metabolic performance.

FitAge captures how lifestyle, training, and metabolic health influence biological resilience and performance capacity. A lower FitAge relative to chronological age indicates stronger aerobic conditioning and metabolic flexibility, while a higher FitAge may suggest deconditioning or systemic stress.

Though primarily a research and optimization tool, OMICm FitAge offers valuable insight into how molecular-level regulation corresponds to physical performance and longevity potential.

Category: Epigenetics

Level: Advanced

Usefulness: Low

Level

Advanced

This is an advanced-level test intended for users engaged in long-term health optimization or performance tracking. It is best interpreted in combination with physical performance data such as VO₂max, HRV, and body composition metrics.

Usefulness

Low

OMICm FitAge bridges the gap between molecular biomarkers and physical performance by estimating a fitness-based biological age. However, due to current model limitations, it should be viewed as exploratory rather than diagnostic.
Functional aging insight

Provides an estimate of biological age based on physical fitness and metabolic efficiency markers.

Training feedback tool

Can complement performance testing (e.g., PNOE or VO₂max) by showing molecular adaptation to exercise and recovery.

Limited clinical precision

Predictive accuracy remains modest; results are best used to monitor long-term lifestyle and training effects.

How it works

The FitAge model was trained on datasets linking DNA methylation signatures with physiological parameters such as VO₂max, lean body mass, and mitochondrial efficiency. The methylation profile is then compared to population norms to derive a predicted “fitness age.”
DNA methylation profiling

Blood DNA is analyzed for methylation patterns associated with metabolic and muscular function genes.

Predictive modeling

A regression algorithm calculates biological fitness age relative to chronological age, generating an “age delta” that reflects fitness-related molecular health.

Measures

The OMICm FitAge report includes key measures reflecting metabolic and performance-related biological aging.
FitAge (Epigenetic Fitness Age)

The predicted biological age derived from methylation signatures correlated with cardiorespiratory and muscular performance.

FitAge Delta

The difference between FitAge and chronological age; a negative delta suggests a younger, fitter molecular profile.

Fitness Percentile

Indicates how the user’s FitAge compares to population averages of similar sex and age.

Reliability

While based on scientifically grounded correlations between methylation and fitness parameters, the model’s predictive power remains lower than direct physiological assessments.
Validation level

Early-stage validation with moderate correlations to measured VO₂max and functional fitness indices.

External variability

Physical activity, sleep, and stress can transiently influence methylation states, affecting short-term reproducibility.

Limitations

OMICm FitAge provides exploratory insights but is not a replacement for physiological performance testing.
Limited dataset size

Current predictive models are trained on smaller populations and may not generalize across diverse ethnic groups.

Indirect measurement

Estimates fitness capacity from molecular patterns, not from direct exercise performance or energy output.

Frequency

Suggested cadence

Once per year or after significant lifestyle or training changes to monitor molecular-level fitness adaptation.

Cost

Typical costs

Approximately €300–500 when included within the full TruDiagnostic panel or as part of an advanced epigenetic package.

Availability

Where available

Offered by TruDiagnostic and partner longevity or performance clinics as part of the OMICm-based epigenetic suite.

Preparation

How to prepare

No special preparation required. Avoid acute inflammation or intense exercise in the 48 hours preceding blood draw for optimal stability of methylation markers.

Interpretation

The report provides a comparison between your FitAge and chronological age, along with percentile positioning.
FitAge younger than chronological age

Suggests superior metabolic and cardiovascular health, indicating effective adaptation to training and recovery.

FitAge older than chronological age

May point to low fitness levels, overtraining, or lifestyle-related metabolic strain — adjust recovery and exercise balance accordingly.

Alternatives

Exercise Metabolic Test (PNOE)

Provides direct measurement of VO₂max and substrate utilization, offering complementary physiological data to FitAge.

GlycanAge

Evaluates biological aging from immune and inflammatory perspective rather than metabolic fitness.

FAQ

Is OMICm FitAge equivalent to a VO₂max test?

No. It estimates molecular correlates of fitness but does not measure actual oxygen uptake or performance thresholds.

Can lifestyle changes affect FitAge?

Yes. Sustained exercise, improved sleep, and metabolic optimization can shift methylation patterns toward a younger FitAge profile over time.

How accurate is OMICm FitAge?

It provides a general molecular correlate of fitness but should be interpreted as complementary to physical testing, not a replacement.