SYMPHONY Age (TruDiagnostic)

Epigenetic system-level biological age assessment across 11 physiological domains.

SYMPHONY Age (TruDiagnostic)

Table of contents

Basic data

The SYMPHONY Age test by TruDiagnostic is an advanced epigenetic analysis that estimates biological aging across multiple organ systems. Using DNA methylation data, it models the biological age of 11 distinct physiological domains, including cardiovascular, immune, metabolic, neurological, and endocrine systems.

This multi-system approach allows for a more granular understanding of how different parts of the body age relative to one another. For example, an individual may show a younger cardiovascular age but an older immune age, reflecting specific stressors or lifestyle influences.

Although SYMPHONY Age provides rich contextual data, it is primarily a research and optimization tool rather than a diagnostic instrument. Interpretation requires understanding of systemic aging processes and integration with additional biomarkers.

Category: Epigenetics

Level: Advanced

Usefulness: Low

Level

Advanced

This is an advanced-level diagnostic for individuals already familiar with biological age testing and seeking to understand aging patterns across organ systems. It is best used as part of a comprehensive longevity assessment combining molecular, physiological, and lifestyle data.

Usefulness

Low

SYMPHONY Age offers deeper insights into biological aging at the system level, helping users identify which organ systems may be aging faster than others. However, it provides limited direct clinical actionability.
Multi-system aging profile

Breaks down biological aging across 11 domains, such as cardiovascular, immune, metabolic, and neurological systems.

Personalized longevity insight

Identifies the systems contributing most to overall biological age acceleration, guiding targeted interventions.

Limited standalone value

Results should be interpreted in the context of other biological markers, functional testing, and lifestyle data.

How it works

The test analyzes DNA methylation patterns linked to system-specific biological processes using large-scale machine learning models trained on multi-omic datasets.
System-level modeling

Epigenetic signatures correlated with physiological function and disease risk are used to calculate individual system ages.

Aggregation into composite age

The 11 organ system ages are averaged and weighted to provide a summary view of the user’s overall biological profile.

Measures

The SYMPHONY report provides 11 separate biological age estimates, each representing a physiological system.
Cardiovascular System Age

Reflects the biological integrity of vascular and cardiac tissues based on methylation of genes involved in endothelial function and inflammation.

Immune System Age

Indicates immune competence and inflammation balance, capturing changes in adaptive and innate immune pathways.

Metabolic System Age

Represents metabolic flexibility, insulin sensitivity, and mitochondrial regulation as inferred from DNA methylation signatures.

Neurological System Age

Suggests neuroplasticity and resilience of central nervous system pathways, reflecting stress and neuroinflammation.

Endocrine and Hormonal System Age

Models hormonal regulation and balance across thyroid, adrenal, and reproductive axes.

Reliability

SYMPHONY Age is based on validated epigenetic models but remains a research-oriented tool. Variability between tissue types and populations can influence precision.
Technical reliability

High reproducibility under standardized lab conditions, but inter-system comparisons should be interpreted cautiously.

Biological complexity

System-level scores depend on complex methylation networks that may not directly reflect organ pathology.

Limitations

While the SYMPHONY Age test offers valuable insights, it should not be used for medical diagnosis or organ-specific disease detection.
Limited clinical application

Currently used primarily for research and longevity optimization rather than medical diagnostics.

Model transparency

The proprietary algorithm and weighting methods are not publicly disclosed, limiting independent validation.

Frequency

Suggested cadence

Once per year or as part of a longitudinal study to monitor systemic biological aging trends.

Cost

Typical costs

Around €400–700, depending on whether it is bundled within a full TruAge or TruDiagnostic panel.

Availability

Where available

Provided by TruDiagnostic as part of the TruAge Advanced or Complete Panels, and by partner longevity clinics worldwide.

Preparation

How to prepare

No special preparation required. Avoid testing during acute illness or inflammation for more stable methylation readings.

Interpretation

The report provides both system-specific and composite aging data, allowing identification of which physiological domains contribute most to overall biological age.
System ages below chronological age

Indicates slower aging in those domains, often linked to effective lifestyle and metabolic resilience.

System ages above chronological age

Highlights potential areas of physiological stress or early dysfunction requiring targeted attention.

Alternatives

OMICm Age (TruDiagnostic)

Provides a single composite biological age score rather than system-specific data.

DunedinPACE (TruDiagnostic)

Measures the rate of aging rather than system-level biological age, offering complementary insights.

FAQ

What makes SYMPHONY Age different from standard biological age clocks?

It breaks biological age down by organ systems, offering more granular insights into how different parts of the body age over time.

Can this test diagnose organ disease?

No. It’s a research-grade model intended for longevity assessment, not a clinical diagnostic tool.

How can I use this information?

Focus on systems showing higher biological age and apply targeted interventions — such as exercise, nutrition, and stress management — to support systemic rejuvenation.