Ghk-cu and skin peptides (topical)

Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective

Type of study: literature review

Number of citations: 0

Year: 2024

Authors: S. Mortazavi, Seyyed Ali Mohammadi Vadoud, Hamid Reza Moghimi

Journal: BioImpacts : BI

Journal ranking: Q2

Key takeaways: GHK-Cu and Pal-GHK are effective anti-wrinkle peptides with potential for increased skin permeability through permeation enhancement methodologies.

Abstract: Introduction: Peptides are promising and attractive anti-wrinkle active ingredients, amongst which glycyl-histidyl-lysine peptide (GHK) is one of the most broadly promoted peptide for topical application. This simple sequence of amino acid residues not only has the capability of tissue regeneration and the enhancement of collagen and glycosaminoglycans synthesis but also is able to increase nerve outgrowth and angiogenesis. Consequently, GHK has several properties, from wound healing to prevention/reduction wrinkles. GHK-Cu and Pal-GHK are metal complex and palmitoylated derivatives of GHK, respectively. Although GHK-Cu and Pal-GHK are widely used in anti-wrinkle products available on the cosmetic market, the published information on their skin permeability, effectiveness, physicochemical properties and so on is insufficient. Methods: This review aims to highlight whether GHK is sufficiently effective on wrinkle prevention/reduction. Apart from the effectiveness, another question that is tried to be answered is whether skin permeability of GHK allows it to act as an anti-wrinkle peptide at its site of action? Skin permeation enhancement methods employed so far are also reviewed. Results: Based on cellular studies, undoubtedly, GHK can be considered as an anti-wrinkle ingredient. Although GHK-Cu and Pal-GHK have been of interest as effective peptides to be incorporated in the anti-wrinkle products, there is a surprising absence of clinical studies using them. Metal complexation and chemical modification with a hydrophobic moiety increase permeability of this peptide. Besides, cell penetrating peptides seem promising to increase skin permeation of GHK and its derivatives. Skin pretreatment with microneedles also has the potential to be further studied for permeation enhancement of such peptides. As peptide ingredients, their formulation may encounter some challenges, mainly due to their hydrophilic (high aqueous solubility and low partition coefficient) and unstable nature. Conclusion: Although GHK-Cu and Pal-GHK are effective and relatively skin permeable, their permeability could be successfully increased using permeation enhancement methodologies.

Skin Regenerative and Anti-Cancer Actions of Copper Peptides

Type of study:

Number of citations: 21

Year: 2018

Authors: L. Pickart, A. Margolina

Journal: Cosmetics

Journal ranking: Q2

Key takeaways: Copper peptides, such as GHK-Cu, have potent anti-cancer properties and can improve skin regeneration and appearance.

Abstract: Topical remedies capable of protecting skin from damage and supporting its regeneration can improve skin’s health as well as its appearance. Small copper peptides have an excellent safety record and are widely used in cosmetic products. The most studied copper peptide is GHK-Cu (glycyl-L-histidyl-L-lysine), a small copper-binding peptide, naturally present in human plasma. Since its discovery in 1973, in vivo and in vitro studies have shown that GHK-Cu possesses a wealth of health-positive actions including improving wound contraction and epithelization, and increasing the production of growth factors and activity of antioxidant enzymes. Recently, gene expression profiling shed new light on diverse biological actions of GHK-Cu. The present paper discusses evidence of GHK-Cu and other small copper peptides possessing potent anti-cancer properties.

Topical Peptide Treatments with Effective Anti-Aging Results

Type of study:

Number of citations: 129

Year: 2017

Authors: S. Schagen

Journal: Cosmetics

Journal ranking: Q2

Key takeaways: Topical peptides like copper tripeptide, palmitoyl pentapeptide-4, and carnosine show promising anti-aging results in controlled in vivo studies.

Abstract: In the last two decades, many new peptides have been developed, and new knowledge on how peptides improve the skin has been uncovered. The spectrum of peptides in the field of cosmetics is continuously growing. This review summarizes some of the effective data on cosmeceutical peptides that work against intrinsic and extrinsic aging. Some peptides have been proven in their efficacy through clinical skin trials. Well-known and documented peptides like copper tripeptide are still under research to obtain more details on their effectiveness, and for the development of new treatments. Palmitoyl pentapeptide-4 and Carnosine are other well-researched cosmeceuticals. Additionally, there are many more peptides that are used in cosmetics. However, study results for some are sparse, or have not been published in scientific journals. This article summarizes topical peptides with proven efficacy in controlled in vivo studies.

Rigid-flexible nanocarriers loaded with active peptides for antioxidant and anti-inflammatory applications in skin.

Type of study:

Number of citations: 2

Year: 2024

Authors: Yan Wang, Jialiang Lin, Zihao Yu, Jinbo Cheng, Jianhua Cheng, Weikang Cui

Journal: Colloids and surfaces. B, Biointerfaces

Journal ranking: Q1

Key takeaways: This novel peptide nanocarrier effectively counteracts cellular inflammation, senescence, and apoptosis from oxidative damage, offering a green, non-toxic, and convenient antioxidant system for skin aging prevention.

Study of the Skin-penetration Promoting Effect and Mechanism of Combined System of Curcumin Liposomes Prepared by Microfluidic Chip and Skin Penetrating Peptides TD-1 for Topical Treatment of Primary Melanoma.

Type of study: non-rct in vitro

Number of citations: 15

Year: 2023

Authors: Ying-Yin Zhu, Wuqing Xiao, Wanling Zhong, Chen Xi, Jinhong Ye, Qing Zhang, Huichao Wu, Shouying Du

Journal: International journal of pharmaceutics

Journal ranking: Q1

Key takeaways: The combined system of Cur-Lips and skin-penetrating peptide TD-1 effectively promotes skin penetration and has great potential for melanoma prevention and treatment.

Potential role of natural bioactive peptides for development of cosmeceutical skin products

Type of study:

Number of citations: 108

Year: 2019

Authors: J. E. Aguilar-Toalá, A. Hernández‐Mendoza, A. F. González-Córdova, B. Vallejo‐Cordoba, A. Liceaga

Journal: Peptides

Journal ranking: Q2

Key takeaways: Bioactive peptides show potential in improving skin health by providing antioxidant, antimicrobial, and anti-inflammatory properties, and inhibiting aging-related enzymes.

Enhanced skin penetration of curcumin by a nanoemulsion-embedded oligopeptide hydrogel for psoriasis topical therapy.

Type of study:

Number of citations: 1

Year: 2025

Authors: Kehan Chen, Hui Yang, Guo Xu, Yunhan Hu, Xue Tian, Song Qin, Tianyue Jiang

Journal: RSC medicinal chemistry

Journal ranking: Q1

Key takeaways: The Cur-CNEs/Gel, an oligopeptide hydrogel encapsulating curcumin-loaded nanoemulsions, effectively enhances skin penetration and alleviates psoriasis symptoms in mice.

Abstract: Topical delivery of therapeutics on the skin can effectively alleviate skin symptoms of psoriasis and reduce systemic toxicity. However, the low delivery efficiency caused by the stratum corneum barrier limits the therapeutic impact. Here, we reported an oligopeptide hydrogel that encapsulates cell-penetrating-peptide (CPP)-decorated curcumin-loaded nanoemulsions (Cur-CNEs) to enhance the skin penetration of curcumin for topical treatment of psoriasis. After being applied to the skin of psoriatic mice, the Cur-CNE embedded oligopeptide hydrogel (Cur-CNEs/Gel) provided a prolonged residue time of Cur-CNEs on the skin lesion. The fluidic and elastic properties of the nanoemulsions enabled them to effectively pass through the interstitial spaces of the stratum corneum, while the CPP decoration further enhanced skin penetration and cellular uptake of Cur-CNEs. The Cur-CNEs/Gel exhibits effective alleviation of the symptoms of psoriasis in mice and provides a promising strategy for topical treatment of psoriasis.

Ameliorative Effects of Peptides from the Oyster (Crassostrea hongkongensis) Protein Hydrolysates against UVB-Induced Skin Photodamage in Mice

Type of study: non-rct experimental

Number of citations: 41

Year: 2020

Authors: Zhilan Peng, Beibei Chen, Qinsheng Zheng, Guoping Zhu, Wenhong Cao, Xiaoming Qin, Chaohua Zhang

Journal: Marine Drugs

Journal ranking: Q1

Key takeaways: Oyster protein hydrolysates effectively protect against UVB-induced skin photodamage by promoting antioxidant enzymes, decreasing inflammation, and regulating MMP-1 expression.

Abstract: Chronic exposure to ultraviolet B (UVB) irradiation is a major cause for skin photoaging. UVB induces damage to skin mainly by oxidative stress, inflammation, and collagen degradation. This paper investigated the photo-protective effects of peptides from oyster (Crassostrea hongkongensis) protein hydrolysates (OPs) by topical application on the skin of UVB-irradiated mice. Results from mass spectrometry showed that OPs consisted of peptides with a molecular weight range of 302.17–2936.43 Da. In vivo study demonstrated that topical application of OPs on the skin significantly alleviated moisture loss, epidermal hyperplasia, as well as degradation of collagen and elastin fibers caused by chronic UVB irradiation. In this study, OPs treatment promoted antioxidant enzymes (SOD and GPH-Px) activities, while decreased malondialdehyde (MDA) level in the skin. In addition, OPs treatment significantly decreased inflammatory cytokines (IL-1β, IL-6, TNF-α) content, and inhibited inflammation related (iNOS, COX-2) protein expression in the skin. Via inhibiting metalloproteinase 1(MMP1) expression, OPs treatment markedly decreased the degradation of collagen and elastin fibers as well as recovered the altered arrangement of extracellular matrix network in the dermis of skin. Our study demonstrated for the first time that OPs protected against UVB induced skin photodamage by virtue of its antioxidative and anti-inflammatory properties, as well as regulating the abnormal expression of MMP-1. The possible molecular mechanism underlying OPs anti-photoaging is possibly related to downregulating of the MAPK/NF-κB signaling pathway, while promoting TGF-β production in the skin.

The Innovative and Evolving Landscape of Topical Exosome and Peptide Therapies: A Systematic Review of the Available Literature

Type of study: systematic review

Number of citations: 8

Year: 2024

Authors: Makenna Ash, Meira Zibitt, Orr Shauly, Ambika Menon, A. Losken, Daniel J Gould

Journal: Aesthetic Surgery Journal. Open Forum

Journal ranking: brak

Key takeaways: Topical exosomes and peptides show promise for skin rejuvenation, with potential for safe and effective treatment in early trials.

Abstract: Abstract   Topical antiaging therapies provide noninvasive delivery of active therapeutics. Exosomes, or extracellular nanovesicles, and peptides, small strings of amino acids, have shown promise as topical therapies in early trials, but neither is FDA approved. This review aims to elucidate the current and future landscape of topical exosomes and peptides as therapeutics for skin rejuvenation. A literature search was conducted using the keywords “peptides” OR “exosomes” AND “skin” OR “rejuvenation.” Primary endpoints included mechanisms of action in humans or live animals as well as clinical data supporting the use of exosomes or peptides topically for skin rejuvenation or wound healing. Secondary endpoints were safety, side effects, and efficacy. The articles were collected, organized, and sorted using the Covidence software (Melbourne, Australia) for systematic review. Nine articles evaluating topical application of exosomes and 9 of peptides met inclusion criteria. Topical exosomes were found to increase collagen deposition, accelerate wound healing, and improve overall cosmesis. Several clinical trials are currently underway. Topical peptides were found to improve appearance of fine lines and wrinkles, elasticity and viscoelasticity, skin texture, skin thickness, and the potential for accelerated wound healing. Peptides are quite common in “cosmeceutical” products, and several patents have been filed for topical peptide products aimed at increasing skin rejuvenation. This could indicate a movement toward pursuing FDA approval. The future of topical exosome and peptide products for the purpose of skin rejuvenation appears promising. Preliminary data from the studies reviewed here indicates that these products have the potential to be safe and effective. Level of Evidence: 3

Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application

Type of study: non-rct in vitro

Number of citations: 10

Year: 2023

Authors: Tian-Hu Liu, Ying Liu, Xiaoyu Zhao, Liguo Zhang, Wei Wang, De Bai, Y. Liao, Zhenyuan Wang, Mi Wang, Jiaheng Zhang

Journal: Bioactive Materials

Journal ranking: Q1

Key takeaways: Thermodynamically stable ionic liquid microemulsions improve local delivery of copper peptides, potentially enhancing hair growth treatment without invasive methods.

Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study.

Type of study: rct

Number of citations: 12

Year: 2023

Authors: Miyeong Lee, Eunjoung Kim, H. Ahn, S. Son, Hyunjun Lee

Journal: Food & function

Journal ranking: Q1

Key takeaways: Oral intake of collagen peptide NS, containing Gly-Pro and Pro-Hyp, significantly improves skin hydration, elasticity, desquamation, and wrinkling in women aged 30 to 60 years without causing side effects.

Abstract: Collagen hydrolysate, which contains bioactive peptides, is used as a dietary supplement for the refinement of elasticity, hydration, desquamation, and wrinkling of aging human skin. Here, we conducted a double-blind, randomized, and placebo-controlled oral administration study on the effects of a collagen peptide (CPNS) containing dipeptides, including Gly-Pro and Pro-Hyp, on skin wrinkling, desquamation, elasticity, and hydration. Our results show that an intake of 1650 mg per day of CPNS for 12 weeks had beneficial effects on skin health in a cohort of women aged from 30 to 60 years (n = 100). Compared with the placebo group, skin desquamation, hydration, skin wrinkling, and elasticity were significantly improved after 4, 4, 12, and 12 weeks of administration, respectively. In a safety test of CPNS ingestion, none of the participants showed any side effects during the clinical study period. These results demonstrate that the low molecular weight bioactive peptides contained in CPNS, such as Gly-Pro and Pro-Hyp, exert positive effects on skin hydration, elasticity, desquamation, and wrinkling.

Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation

Type of study:

Number of citations: 130

Year: 2020

Authors: Gabriel Aguirre-Cruz, A. León-López, Verónica Cruz-Gómez, R. Jiménez-Alvarado, G. Aguirre-Álvarez

Journal: Antioxidants

Journal ranking: Q1

Key takeaways: Hydrolyzed collagen improves skin elasticity, moisture, and protects against UV melasma, making it a safe and effective antioxidant for both oral and topical use.

Abstract: Antioxidants are molecules that delay or inhibit the oxidation of other molecules. Its use significantly increased in recent years in the diet of people. Natural antioxidants are replacing the use of synthetic antioxidant ingredients due to their safety, nutritional, and therapeutic values. Hydrolyzed collagen (HC) is a popular ingredient considered to be an antioxidant. This low molecular weight protein has been widely utilized due to its excellent biocompatibility, easy biodegradability, and weak antigenicity. It is a safe cosmetic biomaterial with good moisturizing properties on the skin. The antioxidant properties of HC are conditioned to the size of the molecule: the lower the molecular weight of peptides, the greater the ability to donate an electron or hydrogen to stabilize radicals. The antioxidant capacity of HC is mostly due to the presence of hydrophobic amino acids in the peptide. The exact mechanism of peptides acting as antioxidants is not clearly known but some aromatic amino acids and histidine are reported to play an important role in the antioxidant activity. Oral ingestion of HC increases the levels of collagen-derived peptides in the blood torrent and improves the skin properties such as elasticity, skin moisture, and transepidermal water loss. Additionally, daily intakes of HC protect the skin against UV melasma, enhances the fibroblast production and extracellular matrix of the skin. HC has been identified as a safe cosmetic ingredient for topical formulations with good moisturizing properties at the stratum corneum layer of the skin. It reduces the effects of skin aging (dryness, laxity, and wrinkles). The use of HC as a principal ingredient in safe formulations for skin protection was reviewed and compared when it is used by topical and/or oral administration.

Antioxidant activity and inhibition of ultraviolet radiation-induced skin damage of Selenium-rich peptide fraction from selenium-rich yeast protein hydrolysate.

Type of study: non-rct experimental

Number of citations: 44

Year: 2020

Authors: Hengke Guo, Siyu Guo, Hongmei Liu

Journal: Bioorganic chemistry

Journal ranking: Q1

Key takeaways: Se-rich yeast peptide fraction containing selenium and bioactive peptides shows the highest antioxidant activity and effectively reduces UVB radiation-induced skin damage.

A new peptide originated from amphibian skin alleviates the ultraviolet B-induced skin photodamage.

Type of study: non-rct experimental

Number of citations: 18

Year: 2022

Authors: Siyu Wang, Meifeng Yang, Saige Yin, Yingxuan Zhang, Yue Zhang, Huiling Sun, Longjun Shu, Yixiang Liu, Zijian Kang, Naixin Liu, Jiayi Li, Ying Wang, Li He, Mingying Luo, Xinwang Yang

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Journal ranking: Q1

Key takeaways: OA-GI13, a novel amphibian-derived peptide, effectively reduces ultraviolet B-induced skin photodamage by increasing antioxidant levels and protecting the skin against UVB irradiation.

Oral Intake of Chicken Bone Collagen Peptides Anti-Skin Aging in Mice by Regulating Collagen Degradation and Synthesis, Inhibiting Inflammation and Activating Lysosomes

Type of study: non-rct experimental

Number of citations: 41

Year: 2022

Authors: Changwei Cao, Zhichao Xiao, H. Tong, Yuntao Liu, Yinglong Wu, C. Ge

Journal: Nutrients

Journal ranking: Q1

Key takeaways: Oral intake of chicken bone collagen peptides effectively reduces skin aging in mice by promoting collagen synthesis, inhibiting degradation, and reducing inflammation.

Abstract: The effect of diet on skin aging has become an interesting research topic. Previous studies have mostly focused on the beneficial effects of collagen peptides derived from marine organisms on the aging skin when administered orally, while the beneficial effects of collagen peptides derived from poultry on aging skin have been rarely reported. In this study, collagen peptides were prepared from chicken bone by enzymatic hydrolysis, and the effect and mechanism of action of orally administered collagen peptides on alleviating skin aging induced by UV combined with D-galactose were investigated. The results showed that the chicken bone collagen had typical characteristics of collagen, and the chicken bone collagen peptides (CPs) were mainly small molecular peptides with a molecular weight of <3000 Da. In vivo experiments showed that CPs had a significant relieving effect on aging skin, indicated by the changes in the compostion and structure of the aging skin, improvement of skin antioxidant level, and inhibition of inflammation; the relieving effect was positively correlated with the dose of CPs. Further investigation showed that CPs first reduce the level of skin oxidation, inhibit the expression of the key transcription factor AP-1 (c-Jun and c-Fos), then activate the TGF-β/Smad signaling pathway to promote collagen synthesis, inhibit the expression of MMP-1/3 to inhibit collagen degradation, and inhibit skin inflammation to alleviate skin aging in mice. Moreover, the skin transcriptome found that lysosomes activated after oral administration of CPs may be an important pathway for CPs in anti-skin aging, and is worthy of further research. These results suggested that CPs might be used as a functional anti-aging nutritional component.

The topical application of Sphistin12-38 in combination with sponge spicules for the acne treatment.

Type of study: non-rct experimental

Number of citations: 0

Year: 2024

Authors: Weiyi He, Chi Zhang, Huijung Lai, Guopeng Wu, Ming Xiong, Hui Peng, Ming Chen, Ke Wang

Journal: Drug delivery and translational research

Journal ranking: Q1

Key takeaways: Sph_12-38 combined with sponge spicules effectively treats acne, with a cure rate of 100% in vivo for rabbit ear acne after two weeks.

Abstract: We demonstrated for the first time that a marine-derived antimicrobial peptide (AMP), Sph_12-38, exhibit high antimicrobial activity against P. acnes with a minimum bactericidal concentration (MBC) value of 7 μM. Meanwhile, Sph_12-38 has no significant cytotoxicity to human keratinocytes (HKs) at its high concentration (33.5 μM). The topical application of sponge Haliclona sp. spicules (SHS) dramatically enhanced the skin penetration of Sph_12-38 up to 40.9 ± 5.9% (p < 0.01), which was 6.1 ± 0.9-fold higher than that of Sph_12-38 alone. Further, SHS resulted in the accumulation of most Sph_12-38 in viable epidermis and dermis. Further, the combined use of Sph_12-38 and SHS resulted in a cure rate of 100% for rabbit ear acne treatment in vivo for two weeks, while the one induced by other groups was 40%, 0% and 0% for SHS alone, Sph_12-38 alone and control group, respectively. The strategy of combined using AMP and SHS can also be applied in a rational designed topical delivery system for the management of other deep infection of the skin. The effectiveness of SHS by itself on the treatment of acne was also demonstrated by clinical trials. After 14 days of treatment by 1% SHS gel. The number of skin lesions decreased by 51.4%.Graphical Abstract

Development and Challenges of Antimicrobial Peptides for Therapeutic Applications

Type of study:

Number of citations: 402

Year: 2020

Authors: Charles H. Chen, T. Lu

Journal: Antibiotics

Journal ranking: Q1

Key takeaways: Antimicrobial peptides show potential as therapeutic drugs, but their stability and toxicity require understanding their mechanisms and effects on the human body.

Abstract: More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have been approved by the U.S. Food and Drug Administration (FDA). Now commercialized, these seven peptides have mostly been utilized for topical medications, though some have been injected into the body to treat severe bacterial infections. To understand the translational potential for AMPs, we analyzed FDA-approved drugs in the FDA drug database. We examined their physicochemical properties, secondary structures, and mechanisms of action, and compared them with the peptides in the AMP database. All FDA-approved AMPs were discovered in Gram-positive soil bacteria, and 98% of known AMPs also come from natural sources (skin secretions of frogs and toxins from different species). However, AMPs can have undesirable properties as drugs, including instability and toxicity. Thus, the design and construction of effective AMPs require an understanding of the mechanisms of known peptides and their effects on the human body. This review provides an overview to guide the development of AMPs that can potentially be used as antimicrobial drugs.

The Effect of Secretory Factors of Adipose-Derived Stem Cells on Human Keratinocytes

Type of study:

Number of citations: 108

Year: 2012

Authors: K. Moon, Y. Park, Jae Seol Lee, Yong-Byung Chae, Moon‐Moo Kim, Dong-Soo Kim, Byung-Woo Kim, S. Nam, Jong-Hwan Lee

Journal: International Journal of Molecular Sciences

Journal ranking: Q1

Key takeaways: Advanced Adipose-Derived Stem Cell Protein Extract (AAPE) activates human keratinocyte proliferation and migration, highlighting its potential for skin regeneration treatment.

Abstract: The beneficial effects of adipose-derived stem cell conditioned medium (ADSC-CM) on skin regeneration have been reported. Although the mechanism of how ADSC-CM promotes skin regeneration is unclear, ADSC-CM contained various growth factors and it is an excellent raw material for skin treatment. ADSC-CM produced in a hypoxia condition of ADSC—in other words, Advanced Adipose-Derived Stem cell Protein Extract (AAPE)—has great merits for skin regeneration. In this study, human primary keratinocytes (HKs), which play fundamental roles in skin tissue, was used to examine how AAPE affects HK. HK proliferation was significantly higher in the experimental group (1.22 μg/mL) than in the control group. DNA gene chip demonstrated that AAPE in keratinocytes (p < 0.05) notably affected expression of 290 identified transcripts, which were associated with cell proliferation, cycle and migration. More keratinocyte wound healing and migration was shown in the experimental group (1.22 μg/mL). AAPE treatment significantly stimulated stress fiber formation, which was linked to the RhoA-ROCK pathway. We identified 48 protein spots in 2-D gel analysis and selected proteins were divided into 64% collagen components and 30% non-collagen components as shown by the MALDI-TOF analysis. Antibody array results contained growth factor/cytokine such as HGF, FGF-1, G-CSF, GM-CSF, IL-6, VEGF, and TGF-β3 differing from that shown by 2-D analysis. Conclusion: AAPE activates HK proliferation and migration. These results highlight the potential of the topical application of AAPE in the treatment of skin regeneration.

In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14

Type of study: non-rct in vitro

Number of citations: 6

Year: 2022

Authors: Alessandra Zonari, L. Brace, T. Alencar-Silva, W. F. Porto, Daniel A. Foyt, Mylieneth Guiang, Edgar Andres Ochoa Cruz, O. Franco, Carolina R. Oliveira, Mariana Boroni, J. L. Carvalho

Journal: Toxicology Reports

Journal ranking: Q2

Key takeaways: Peptide 14 is a promising senotherapeutic molecule with a positive safety profile, showing no significant irritation or cellular toxicity in human skin and cancer cells.

Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy.

Type of study: non-rct in vitro

Number of citations: 48

Year: 2014

Authors: J. Sallach, G. Di Pasquale, F. Larcher, Nadine Niehoff, M. Rübsam, A. Huber, J. Chiorini, D. Almarza, S. Eming, Hikmet Ulus, S. Nishimura, U. Hacker, M. Hallek, C. Niessen, H. Büning

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Journal ranking: Q1

Key takeaways: Tropism-modified AAV vectors with novel receptors significantly improve cutaneous gene therapy by increasing cell entry efficiency and targeting v8 integrin, overcoming safety concerns.